Blog Posts - Beta Amyloid



Glaucoma drug brimonidine may have potential to treat Alzheimer's disease

In trials on rats, the drug brimonidine, which is routinely used to lower eye pressure in glaucoma patients, has been found to reduce the formation of amyloid proteins in the retina, which are believed to be linked to Alzheimer's. The resea...
by PolygenicBlog on Dec 13, 2016

Gamma frequency entrainment attenuates amyloid load and modifies microglia : Nature : Nature Research

Changes in gamma oscillations (20–50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. Here we show reduced, behaviourally driven gamma oscillations...
by PolygenicBlog on Dec 8, 2016

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease : Nature

Alzheimer’s disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearan...
by PolygenicBlog on Sep 1, 2016

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease : Scientific Reports

Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features of Alzheimer’s disease (AD). In addition to astrocyte and microglial reactivity, emerging evidence suggests a role of gut microbiota in regulating innate immun...
by PolygenicBlog on Aug 2, 2016

Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques.

It has long been known that spirochetes form clumps or micro colonies in vitro and in vivo. Cortical spirochetal colonies in syphilitic dementia were considered as reproductive centers for spirochetes. Historic and recent data demonstrate that senile...
by PolygenicBlog on Jul 12, 2016

Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. - PubMed - NCBI

 "INTRODUCTION: Alzheimer's disease (AD) is associated with the accumulation of β-amyloid (Aβ) as senile plaques in the brain, thus leading to neurodegeneration and cognitive impairment. Plaque formation depends not merely on the amount of gen...
by PolygenicBlog on Mar 18, 2016

Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model - IOS Press

Senile amyloid plaques are one of the main hallmarks of Alzheimer’s disease (AD). They correspond to insoluble deposits of amyloid-β peptides (Aβ) and are responsible for the inflammatory response and neurodegeneration that lead to loss of memory...
by PolygenicBlog on Jan 28, 2016

Benefits of Grapes For Body and Skin Health

Benefits of Grapes For Body and Skin Health ereadinginformation.com – The benefits of wine has been known long ago. Grapes usually served simply as an ingredient or a recipe or used as a grapes syrup. In the euro area has been cultivated wine 6...
by Reading Information On line on Dec 3, 2015

The case for rejecting the amyloid cascade hypothesis : Nature Neuroscience : Nature Publishing Group

Alzheimer's disease (AD) is a biologically complex neurodegenerative dementia. Nearly 20 years ago, with the combination of observations from biochemistry, neuropathology and genetics, a compelling hypothesis known as the amyloid cascade hypothesis w...
by PolygenicBlog on Nov 20, 2015

Time to Dismount | Journal of Alzheimer's Disease

The field of Alzheimer research has reached an impasse after more than 100,000 clinical and scientific papers published in the last 40 years, because there is yet no hope, no effective treatment, and no knowledge of what causes this dementia. It ha...
by PolygenicBlog on Nov 11, 2015

Characterizing Apolipoprotein E ε4 Carriers and Noncarriers With the Clinical Diagnosis of Mild to Moderate Alzheimer Dementia and Minimal β-Amyloid Peptide Plaques

Importance  β-Amyloid peptide (Aβ) plaques are a cardinal neuropathologic feature of Alzheimer disease (AD), yet more than one-third of apolipoprotein E ε4 (APOE4) noncarriers with the clinical diagnosis of mild to moderate Alzheimer dem...
by PolygenicBlog on Aug 27, 2015

Herpes simplex virus type 1 infection in neurons leads to production and nuclear localization of APP intracellular domain (AICD): implications for Alzheimer's disease pathogenesis.

Several data indicate that neuronal infection with herpes simplex virus type 1 (HSV-1) causes biochemical alterations reminiscent of Alzheimer's disease (AD) phenotype. They include accumulation of amyloid-β (Aβ), which originates from the cleava...
by PolygenicBlog on May 1, 2015

Does Amyloid Kill in Alzheimer’s, Heal in MS?

Beta-amyloid, ...........a suspected culprit in Alzheimer's disease but many amyloid directed trials have failed:- Steinman’s team questioned whether aβ is a villain at all. This helped them to try an unusual experiment that may pay off in spades...
by PolygenicBlog on Mar 13, 2015

PLOS ONE: Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

Accumulation of β-Amyloid (βA) is a key pathogenetic factor in Alzheimer's disease; however, the normal function of βA is unknown. Recent studies have shown that βA can inhibit growth of bacteria and fungi. In this paper we show that βA also...
by PolygenicBlog on Jul 9, 2014

New Research for Alzheimer’s Disease Treatment

Researchers at the Unit of Medicine Design and Molecular Topology at the University of Valencia have discovered eight new active molecules working against Alzheimer’s disease by a mechanism of action... Read More The post New Research for...
by Zintro Blog on May 14, 2014

Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Identifying disease-modifying therapies for Alzheimer’s disease (AD) has been an insurmountable challenge. To provide a new discovery tool for high-throughput compound screening, we used a simple yeast model that makes toxic amounts of β-amyloid (...
by PolygenicBlog on Mar 18, 2014

SFN:Antimicrobial activity of soluble Aβ oligomers is mediated by the VHHQKL heparin-binding domain

 The β-amyloid protein (Aβ) plays a key role in the pathogenesis of Alzheimer's disease. The Aβ peptide sequence includes a VHHQKL heparin-binding domain. Although pathological activities mediated by Aβ’s VHHQKL domain have been extensivel...
by PolygenicBlog on Nov 10, 2013

SFN Transgenic Caenorhabditis elegans and transfected cultured cells expressing human Abeta resist infection by salmonella typhimurium

 Our laboratory recently reported that synthetic Abeta peptide has in vitro antimicrobial activity against at least six human pathogens. More recently we presented data suggesting Abeta binding and antimicrobial activity against pathogenic forms...
by PolygenicBlog on Nov 10, 2013

Antibodies bound to Aβ oligomers potentiate the neurotoxicity of Aβ by activating microglia.

 Beta amyloid (Aβ) oligomers are thought to contribute to the pathogenesis of Alzheimer’s disease. However, clinical trials using Aβ immunization were unsuccessful due to strong brain inflammation, the mechanisms of which are poorly understo...
by PolygenicBlog on Oct 30, 2013

Antibodies bound to Aβ oligomers potentiate the neurotoxicity of Aβ by activating microglia.

 Beta amyloid (Aβ) oligomers are thought to contribute to the pathogenesis of Alzheimer’s disease. However, clinical trials using Aβ immunization were unsuccessful due to strong brain inflammation, the mechanisms of which are poorly understo...
by PolygenicBlog on Oct 30, 2013


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