Blog Posts - Decompensated Cirrhosis



ALLY-1 Trial Results Show Investigational Daclatasvir-Based Regimen Cures 94% of Post-Liver Transplant Patients with Hepatitis C and Up to 94% of Hepatitis C Patients with Cirrhosis (Child-Pugh Class A or B)

97% of post-transplant patients with HCV genotype 1a achieved cure 91% of post-transplant patients with HCV genotype 3 achieved cure  No need seen to alter existing transplantation medication regimens Saturday, April 25, 2015 10:00 am EDT...
by Hepatitis C Research and News on Apr 25, 2015

Gilead’s Harvoni and Sovaldi Demonstrate Efficacy and Safety among Chronic Hepatitis C Patients with Advanced Liver Disease

-- High Cure Rates in More Than 600 Genotype 1 and 4 Patients With Limited or No Approved Treatment Options -- VIENNA, Austria--(BUSINESS WIRE)--Apr. 23, 2015-- Gilead Sciences, Inc. (Nasdaq: GILD) today announced results from several Phase 2 clinic...
by Hepatitis C Research and News on Apr 23, 2015

Gilead Announces Harvoni Study Results in Chronic Hepatitis C Patients with Advanced Liver Disease and Those Who Failed Prior Treatment

Published: Nov 11, 2014 8:02 a.m. ET - High Cure Rates in Nearly 800 HCV Patients with Advanced Liver Disease - BOSTON, Nov 11, 2014 (BUSINESS WIRE) -- Gilead Sciences, Inc. GILD, +0.55% today announced results from several Phase 2 and Phase 3 stu...
by Hepatitis C Research and News on Nov 11, 2014

Transferring Liver Patients May Do More Harm Than Good

Published: Nov 9, 2014 By Ed Susman , Contributing Writer, MedPage Today Action Points Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered to be preliminary until pu...

Janssen Highlights its Hepatitis C Clinical Development Program in Advance of 2014 AASLD

Janssen Highlights its Hepatitis C Clinical Development Program in Advance of 2014 American Association for the Study of Liver Diseases (AASLD) Annual Meeting -- Studies focused on patients where there is a high unmet need today or anticipated in t...

Magnetic resonance elastography in compensated and decompensated cirrhosis

Magnetic resonance elastography in compensated and decompensated cirrhosisNon-invasive predictors identifying subjects with compensated liver disease at highest risk for transitioning to a decompensated state are lacking. We hypothesized that l...
by HCV New Drug Research on May 5, 2014

Gilead’s Sovaldi® Demonstrates Efficacy and Safety Among Chronic Hepatitis C Patients with Advanced Liver Disease

- Benefit in Patients with Decompensated Cirrhosis and Recurrent HCV Infection Following Liver Transplantation -- LONDON--(BUSINESS WIRE)--Apr. 11, 2014-- Gilead Sciences, Inc. (Nasdaq: GILD) today announced data from two Phase 2 studies and a comp...
by Hepatitis C Research and News on Apr 11, 2014

Measurement of the quality of care of patients admitted with decompensated cirrhosis

Liver International Volume 34, Issue 2, pages 204–210, February 2014 Cirrhosis and Liver Failure Rony Ghaoui1,*, Jennifer Friderici2, Paul Visintainer2, Peter K. Lindenauer3,4,5, Tara Lagu3,4,5, David Desilets1 Article first published online: 1...

Role of Magnetic Resonance Elastography in compensated and decompensated liver disease

Journal of Hepatology Article in Press Sumeet K. Asrani, Jayant A. Talwalkar, Patrick S. Kamath, Vijay H. Shah, Giovanna Saracino, Linda Jennings, John B. Gross, Sudhakar Venkatesh, Richard L. Ehman Received 12 June 2013; received in revised form...
by Hepatitis C Research and News on Dec 22, 2013

Antiviral drug resistance increases hepatocellular carcinoma: A prospective decompensated cirrhosis cohort study

World J Gastroenterol. 2013 December 7; 19(45): 8373-8381. Published online 2013 December 7. doi: 10.3748/wjg.v19.i45.8373. Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved. Lei Li, Wei Liu, Yu-Han Chen, Chun-Lei Fan...
by Hepatitis C Research and News on Dec 18, 2013

High Risk of Decompensation with Precirrhosis in HIV/HCV + People

Author: Mark Mascolini 14 December 2013 People with precirrhosis and HIV/HCV coinfection run a high risk of liver decompensation, according to results of an 892-person analysis in Spain. The researchers believe precirrhosis patients with HIV/HCV...
by Hepatitis C Research and News on Dec 14, 2013

Treatment of decompensated cirrhosis secondary to hepatitis C with antiviral therapy

J Coll Physicians Surg Pak. 2013 Dec;23(12):833-6. doi: 12.2013/JCPSP.833836. Khokhar N, Qureshi MO, Niazi TK. Department of Gastroenterology / Medicine, Shifa International Hospital, Islamabad. Abstract Objective: To treat decompensated hepatiti...
by Hepatitis C Research and News on Dec 13, 2013

Liver Stiffness Is Associated With Risk of Decompensation, Liver Cancer, and Death in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis

Clin Gastroenterol Hepatol. 2013 Dec;11(12):1573-1584.e2. doi: 10.1016/j.cgh.2013.07.034. Epub 2013 Aug 15. Singh S, Fujii LL, Murad MH, Wang Z, Asrani SK, Ehman RL, Kamath PS, Talwalkar JA. Division of Gastroenterology and Hepatology, Department o...

Effects of entecavir and lamivudine for hepatitis B decompensated cirrhosis: Meta-analysis

World J Gastroenterol. 2013 Oct 21;19(39):6665-78. doi: 10.3748/wjg.v19.i39.6665. Ye XG, Su QM. Xiao-Guang Ye, Qi-Min Su, Department of Infectious Diseases, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong P...
by Hepatitis C Research and News on Oct 28, 2013

Can Chronic Disease Management Programs Improve Outcomes in Patients With Cirrhosis?

GastroenterologyVolume 145, Issue 5 , Pages 1153-1155, November 2013 Christian A. Mayorga, Amit G. Singal published online 23 September 2013. Philip S. Schoenfeld, Section Editor, John Y. Kao, Section Editor Wigg AJ, McCormick R, Wundke R, et al. Eff...
by Hepatitis C Research and News on Oct 24, 2013

Impact of emerging hepatitis C virus treatments on future needs for liver transplantation in France: A modelling approach

Dig Liver Dis. 2013 Oct 9. pii: S1590-8658(13)00422-2. doi: 10.1016/j.dld.2013.08.137. [Epub ahead of print] Deuffic-Burban S, Mathurin P, Rosa I, Bouvier AM, Cannesson A, Mourad A, Canva V, Louvet A, Deltenre P, Boleslawski E, Truant S, Pruvot FR, D...
by Hepatitis C Research and News on Oct 15, 2013

Risk of Liver Decompensation Among HIV/HCV Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy

Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy CORRECTED PROOF Clin Infect Dis. (2013) doi: 10.1093/cid/cit537 First published online: August 14, 2013 A...

Advanced fibrosis raised risk for decompensation in HIV/HCV coinfection

Provided by Healio Macias J. Clin Infect Dis. 2013;doi:10.1093/cid/cit537. August 15, 2013 Hepatitis C therapy is necessary in patients with advanced fibrosis who are coinfected with hepatitis C and HIV because they are at risk for liver decompens...
by Hepatitis C Research and News on Aug 16, 2013

Baseline MELD Score Predicts Hepatic Decompensation during Antiviral Therapy in Patients with Chronic Hepatitis C and Advanced Cirrhosis

PLoS ONE 8(8): e71262. doi:10.1371/journal.pone.0071262 Open Access    Peer-Reviewed Research Article Georg Dultz, Martin Seelhof, Eva Herrmann, Martin-Walter Welker, Mireen Friedrich-Rust, Gerlinde Teuber, Bernd Kronenberger, Micha...

Liver stiffness more predictive of decompensation than biopsy results in HIV/HCV coinfection

Provided by Healio July 9, 2013 Liver stiffness measurement is similarly predictive of overall mortality and more predictive of decompensation than liver biopsy results among patients with HIV/HCV coinfection, according to data presented at the Int...


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