Blog Posts - Microbiome



Parkinson's Disease Linked to Microbiome | Caltech

Caltech scientists have discovered for the first time a functional link between bacteria in the intestines and Parkinson's disease (PD). The researchers show that changes in the composition of gut bacterial populations—or possibly gut bacteria them...
by PolygenicBlog on Dec 3, 2016

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice : Nature Medicine : Nature Research

 Obesity and type 2 diabetes are associated with low-grade inflammation and specific changes in gut microbiota composition1, 2, 3, 4, 5, 6, 7. We previously demonstrated that administration of Akkermansia muciniphila to mice prevents the develop...
by PolygenicBlog on Dec 2, 2016

Wearing contacts changes the eye microbiome

Contact lenses have been linked to the development of inflammatory eye conditions in their wearers. Now a new study characterizes the microbiome of the eye, and reports that there are distinct differences in the ocular microbiome of contact lens wear...
by Pharmaceutical Microbiology on Aug 13, 2016

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease : Scientific Reports

Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features of Alzheimer’s disease (AD). In addition to astrocyte and microglial reactivity, emerging evidence suggests a role of gut microbiota in regulating innate immun...
by PolygenicBlog on Aug 2, 2016

It's All in Your Gut

A study out of Cornell University made the news recently when Maureen Hanson's team found distinct alterations in the gut flora of patients with ME/CFS. The headlines trumpeted the "first" biological marker for the disease in the microbiome.Those of...
by Onward Through the Fog on Jul 9, 2016

All in Your Gut

A study out of Cornell University made the news recently when Maureen Hanson's team found distinct alterations in the gut flora of patients with ME/CFS. The headlines trumpeted the "first" biological marker for the disease in the microbiome.Those of...
by Onward Through the Fog on Jul 9, 2016

Gut Bacteria Consumes Neurochemical (GABA) Linked To Depression

A recently-discovered strain of gut bacteria has been found to consume GABA, a neurochemical found in the brain. The neurotransmitter has a calming effect on the brain, and the bacteria’s reliance on GABA could explain how the&n...
by PolygenicBlog on Jul 7, 2016

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. - PubMed - NCBI

Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it's hypothesiz...
by PolygenicBlog on Jul 1, 2016

Indicator of chronic fatigue syndrome found in gut bacteria

Physicians have been mystified by chronic fatigue syndrome, a condition where normal exertion leads to debilitating fatigue that isn't alleviated by rest. There are no known triggers, and diagnosis requires lengthy tests administered by an expert. Du...
by PolygenicBlog on Jun 28, 2016

Serotonin Activates Bacterial Quorum Sensing and Enhances the Virulence of Pseudomonas aeruginosa in the Host. - PubMed - NCBI

Bacteria in humans play an important role in health and disease. Considerable emphasis has been placed in understanding the role of bacteria in host-microbiome interkingdom communication. Here we show that serotonin, responsible for mood in the brain...
by PolygenicBlog on Jun 25, 2016

Nature plus nurture: the triggering of multiple sclerosis.

Recent clinical and experimental studies indicate that multiple sclerosis develops as consequence of a failed interplay between genetic ("nature") and environmental ("nurture") factors. A large number of risk genes favour an autoimmune response again...
by PolygenicBlog on Jun 24, 2016

Sex-Specific Effects of Arsenic Exposure on the Trajectory and Function of the Gut Microbiome. - PubMed - NCBI

 "The gut microbiome is deeply involved in numerous aspects of human health; however, it can be readily perturbed by environmental toxicants, such as arsenic. Meanwhile, the interaction among host, gut microbiome, and xenobiotics is a very compl...
by PolygenicBlog on Jun 21, 2016

Medicine Meets The Microbiome

The moment a baby enters the world – even before its first breath – the tiny body receives a massive infusion of bacteria, viruses and fungi. For thousands of years, exposure to these microbes has heralded our departure from the largely sterile e...
by Pharmaceutical Microbiology on Jun 14, 2016

U.S. National Microbiome Initiative

Last Friday the White House announced that it was creating a National Microbiome Initiative to bring together scientists to study microbial diversity associated with the human body and our environment. The move will inject $121 million/year into m...
by Pharmaceutical Microbiology on May 27, 2016

Gut microbiota in early pediatric multiple sclerosis: a case-control study. - PubMed - NCBI

BACKGROUND AND PURPOSE: Alterations in the gut microbial community composition may be influential in neurological disease. Microbial community profiles were compared between early onset pediatric multiple sclerosis (MS) and control children similar f...
by PolygenicBlog on May 23, 2016

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor : Nature Medicine

Astrocytes have important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional response to type I interferons (IFN-Is) in astrocytes during experimental CNS autoimmunity and a...
by PolygenicBlog on May 16, 2016

Pancreatic cancer risk linked to changes in mouth bacteria - Medical News Today

The participants were taking part in larger, ongoing studies of cancer risk, where they had been given mouthwash samples when they joined the studies. They were followed for nearly 10 years, during which any cancer diagnoses were noted. When they an...
by PolygenicBlog on Apr 21, 2016

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host|[rsquo]|s metabolism : Molecular Psychiatry

"Major depressive disorder (MDD) is the result of complex gene–environment interactions. According to the World Health Organization, MDD is the leading cause of disability worldwide, and it is a major contributor to the overall global burden of dis...
by PolygenicBlog on Apr 19, 2016

Worm Infection Counters Inflammatory Bowel Disease by Drastically Changing Gut Microbiome

pub-5799224524264318...
by PolygenicBlog on Apr 15, 2016

Translational Psychiatry - Regulation of prefrontal cortex myelination by the microbiota

 "The prefrontal cortex (PFC) is a key region implicated in a range of neuropsychiatric disorders such as depression, schizophrenia and autism. In parallel, the role of the gut microbiota in contributing to these disorders is emerging. Germ-free...
by PolygenicBlog on Apr 6, 2016


Trending Topics

Close